More Examples of Major or "Take" Reactions to Smallpox Vaccination
Formation by days 6-8 post-vaccination of a papule, vesicle, ulcer, or crusted central lesion, surrounded by an area of induration signifies a response to vaccination; this event is referred to as a major reaction or a "take," and usually results in a scar.
Comparison of Reactions for First-Time Vaccinees and Revaccinees
As can be seen in the images below, vaccination sites sometimes resolve more rapidly in revaccinees.
Source: Vaccination reactions in vaccinia-naïve and previously vaccinated volunteers in a clinical study of diluted Dryvax smallpox vaccine enrolled at the NIAID-supported Vaccine Treatment and Evaluation Units at Saint Louis University in 2002.
- Page last reviewed February 7, 2007
- Page last updated February 21, 2003
- Content source: CDC Emergency Risk Communication Branch (ERCB), Division of Emergency Operations (DEO), National Center for Emerging and Zoonotic Infectious Diseases (NCEZID)